Pharma Deals: Belrose Pharma Acquires Enzon’s Advanced Drug Formulation Technology and Associated Clinical Assets
Belrose Pharma has acquired Enzon’s Advanced Drug Formulation Technology (Peglyation Linker Technology) and the associated product pipeline. Acquisition of this technology will enable Belrose Pharma to accelerate creation of improved biologic and small molecule therapies with better treatment outcomes for patients with life-threatening diseases such as breast cancer and pediatric neuroblastoma, and orphan drug diseases such as hereditary angioedema (HAE).
Through this transaction, Belrose Pharma has added to its portfolio both “traditional” permanent PEGylation and the lesser-known releasable PEGylation technologies, as well as compounds based on both technologies. Polyethylene glycol (PEG), when permanently linked to certain compounds, has a long track record of enabling high-value commercial products through sometimes dramatic improvements in in vivo circulation, toxicity, and efficacy. The lesser-known releasable PEGylation technique provides a different set of clinical benefits – including several targeted release options without a corresponding reduction in potency, improved drug loading, pharmacokinetics, and efficacy, and a simplified and potentially shorter clinical path to market.
Acquired Pipeline Assets include
PEG-SN38 (formerly EZN-2208), a Phase III-ready PEGylated conjugate of SN38 (active metabolite or irinotecan – a part of FOLFIRI regimen used in colorectal cancer) with improved properties including parenteral delivery, increased solubility, higher exposure, more profound deoxyribonucleic acid (DNA) damage, inhibition of angiogenesis, and longer half-life compared with native SN38. PEG-SN38 produced positive responses in clinical trials for metastatic breast cancer and pediatric neuroblastoma.
The second program is PEG-C1 Esterase Inhibitor (formerly EZN-3008), a preclinical PEGylated form of plasma-derived C1-Esterase Inhibitor (C1-INH) offering the significant improvement of weekly or bi-weekly subcutaneous or intravenous injections to HAE patients currently limited to twice-weekly infusions for prophylactic use